The spectrum of underlying diseases in children with autoimmune hemolytic anemia
نویسندگان
چکیده
Aim: Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies directed against red blood cells. We aimed to describe clinical presentation, hematologic and biochemical profiles, treatment modalities, underlying diseases outcomes in children suffering from AIHA. 
 Material Method: In a retrospectively manner, we consecutively recrutied 62 (aged 1 month-18 years) with AIHA who had been followed Erciyes University Child Hospital between January, 2000 November, 2017. Results: The mean age at time diagnosis was 61.9±51.9 months (range:1-192) including 28 girls 34 boys. most common complaints included fatigue fever while findings were jaundice hepatosplenomegaly. 22 (35.4%), there comorbid, active, non-specific infection (upper respiratory tract infection, lower diarrhea, urinary infection). At diagnosis, hemoglobin (Hb) level 6.9±2.5 g/dL (range: 5-9). glucocorticoid therapy given majority patients no medical 4 patients. Of primary AIHA, 6 unresponsive one patient responded partially. It found that risk factors 36 secondary as immunodeficiency autoimmune disorders being factors. Conclusion: immunodeficiencies highly prevalent included. By advance whole exome sequencing technology, believe disease our study detected quite high presented children.
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ژورنال
عنوان ژورنال: Journal of health sciences and medicine
سال: 2021
ISSN: ['2636-8579']
DOI: https://doi.org/10.32322/jhsm.985008